Tenuazonic Acid (copper salt) | Cayman Chemical
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Tenuazonic Acid (copper salt)

Item № 11443
Purity ≥98%
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $35.00 0.00
     5 mg $140.00 0.00
     10 mg $252.00 0.00
     25 mg $455.00 0.00

Pricing updated 2018-11-16. Prices are subject to change without notice.

Description
Synonyms
  • AAC-toxin

Tenuazonic acid is one of the major Alternaria mycotoxins commonly found as a natural contaminant in food (LD50 = 548 μg/egg in the chicken embryo toxicity assay).1 Tenuazonic acid contamination has been linked to esophageal cancer in human populations at risk of high exposure. Mice fed 100 mg/kg/day tenuazonic acid orally for 10 months developed precancerous lesions on the esophageal mucosa.2 Microscopic analysis of mucosal epithelial cells from these tenuazonic acid-treated animals reveal pyknosis and marked pleomorphisms in the nuclei, chromatin granulation and increased chromatin mass, irregularities in nuclear contours, and vacuolization in nucleoplasms.2

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Technical Information
Formal Name
3-acetyl-1,5-dihydro-4-hydroxy-5S-[(1S)-1-methylpropyl]-2H-pyrrol-2-one, monocopper salt
Synonyms
  • AAC-toxin
Molecular Formula
C10H15NO3 • Cu
Formula Weight
260.8
Purity
≥98%
Formulation
A crystalline solid
λmax
225, 291 nm
SMILES
O=C1C(C(C)=O)=C(O)[C@@]([C@H](CC)C)([H])N1.[Cu+2]
InChI Code
InChI=1S/C10H15NO3.Cu/c1-4-5(2)8-9(13)7(6(3)12)10(14)11-8;/h5,8,13H,4H2,1-3H3,(H,11,14);/q;+2/t5-,8-;/m0./s1
InChI Key
DBSDTDXIMZIOAC-XMLTWROESA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Griffin, G.F., and Chu, F.S. Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay Applied and Environmental Microbiology 46(6), 1420-1422 (1983).

2. Yekeler, H., Bitmis, K., Ozçelik, N., et al. Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy Toxicologic Pathology 29, 492-497 (2001).

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