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Irisin (human recombinant)

Item № 11451
CAS № 9037-90-5
Purity ≥90% estimated by SDS-PAGE
product image
                (CAS 9037-90-5)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     100 µg $395.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • Fibronectin Type III Domain 5
  • FNDC5
  • FRCP2
  • PeP

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function.1 Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure.2 The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.

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Technical Information
CAS Number
9037-90-5
Synonyms
  • Fibronectin Type III Domain 5
  • FNDC5
  • FRCP2
  • PeP
Purity
≥90% estimated by SDS-PAGE
Source
recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1).
Amino Acids
1-111 (full-length, amino acids 32-143 of FNDC5)
Molecular Weight
12.4 kDa
License
SUMOpro tag was used under non-exclusive license from LifeSensors, Inc.
UniProt Accession №
Q8NAU1

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Stability
≥ 1 year
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Additional Information

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References & Product Citations
Product Description References

1. Kelly, D.P. Irisin, light my fire Science 336, 42-43 (2012).

2. Boström, P., Wu, J., Jedrychowski, M.P., et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481, 463-468 (2012).

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