An anti-inflammatory pentacyclic triterpene
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Isomer(s)
302203-Acetylursolic Acid
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β-acetyl-Boswellic Acid

Item No. 11674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,4β)-3-(acetyloxy)-urs-12-en-23-oic acid
CAS Number
5968-70-7
Synonyms
  • ABA
  • 3-O-acetyl-β-Boswellic acid
  • β-Boswellic acid acetate
Molecular Formula
C32H50O4
Formula Weight
498.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 5 mg/ml
SMILES
C[C@]1(C(O)=O)[C@H](OC(C)=O)CC[C@]2(C)[C@@]3([H])CC=C4[C@](CC[C@]5(C)[C@@]4([H])[C@@H](C)[C@H](C)CC5)(C)[C@]3(C)CC[C@]21[H]
InChi Code
InChI=1S/C32H50O4/c1-19-11-14-28(4)17-18-30(6)22(26(28)20(19)2)9-10-23-29(5)15-13-25(36-21(3)33)32(8,27(34)35)24(29)12-16-31(23,30)7/h9,19-20,23-26H,10-18H2,1-8H3,(H,34,35)/t19-,20+,23-,24-,25-,26+,28-,29-,30-,31-,32?/m1/s1
InChi Key
YJBVHJIKNLBFDX-MWEIDVNDSA-N
Origin
Plant/Boswellia serrata
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $157

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    10 mg

    $293

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    Product Description

    β-acetyl-Boswellic acid is a non-reducing inhibitor of 5-lipoxygenase (5-LO) that shows selectivity for 5-LO over 12-LO or COX.1,2 When studied as a 1:1 mixture with α-acetyl-boswellic acid, it inhibits topoisomerase II activity and arrests cell cycling or induces apoptosis in cancer cells.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Safayhi, H., Mack, T., Sabieraj, J., et al. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146 (1992).

    2. Ammon, H.P., Safayhi, H., Mack, T., et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J. Ethnopharmacol. 38(2-3), 113-119 (1993).

    3. Zhao, W., Entschladen, F., Liu, H., et al. Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detect. Prev. 27(1), 67-75 (2003).

    4. Xia, L., Chen, D., Han, R., et al. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Mol. Cancer Ther. 4(3), 381-388 (2005).