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GW 6471

Item № 11697
CAS № 880635-03-0
Purity ≥98%
product image
                (CAS 880635-03-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $35.00 0.00
     5 mg $123.00 0.00
     10 mg $193.00 0.00
     25 mg $438.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

The peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation.1,2,3 GW 6471 is an antagonist of PPARα (IC50 = 240 nM).4 It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor.4 GW 6471 is used in cell-free, cell lysate, and whole cell systems to examine the impact of PPARα antagonism.5,6,7

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Technical Information
Formal Name
N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-propanamide
CAS Number
880635-03-0
Molecular Formula
C35H36F3N3O4
Formula Weight
619.7
Purity
≥98%
Formulation
A crystalline solid
λmax
225, 278, 347, 352 nm
SMILES
CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C[C@@H](CNC(CC)=O)N/C(C)=C\C(C4=CC=C(C(F)(F)F)C=C4)=O)C=C3
InChI Code
InChI=1S/C35H36F3N3O4/c1-4-33(43)39-22-29(40-23(2)20-32(42)26-12-14-28(15-13-26)35(36,37)38)21-25-10-16-30(17-11-25)44-19-18-31-24(3)45-34(41-31)27-8-6-5-7-9-27/h5-17,20,29,40H,4,18-19,21-22H2,1-3H3,(H,39,43)/b23-20-/t29-/m0/s1
InChI Key
TYEFSRMOUXWTDN-DYQICHDWSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Kersten, S., Desvergne, B., and Wahli, W. Roles of PPARs in health and disease Nature 405(6785), 421-424 (2000).

2. Tenenbaum, A., Motro, M., and Fisman, E.Z. Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessons Cardiovascular Diabetology 4(14), 1-5 (2005).

3. Ahmed, W., Ziouzenkova, O., Brown, J., et al. PPARs and their metabolic modulation: New mechanisms for transcriptional regulation? Journal of Internal Medicine 262, 184-198 (2007).

4. Xu, H.E., Stanley, T.B., Montana, V.G., et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα Nature 415(6873), 813-817 (2002).

5. Wang, W., Lin, Q., Lin, R., et al. PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway Experimental Cell Research 319(10), 1523-1533 (2013).

6. Downer, E.J., Clifford, E., Amu, S., et al. The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α The Journal of Biological Chemisty 287(30), 25440-25453 (2012).

7. Müller, M.Q., de Koning, L.I., Schmidt, A., et al. An innovative method to study target protein-drug interactions by mass spectrometry Journal of Medicinal Chemistry 52(9), 2875-2879 (2009).

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