Pricing updated 2019-07-23. Prices are subject to change without notice.
Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).1,2 At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.3 Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.4 It also has a biphasic effect on P-glycoprotein activity.5
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1. McNamara, F.N., Randall, A., and Gunthorpe, M.J. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1) British Journal of Pharmacology 144(6), 781-790 (2005).
Schöffmann, A., Wimmer, L., Goldman, D., et al. Efficient modulation of γ-
Lee, S.A., Hong, S.S., Han, X.H., et al. Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-
Murray, M. Toxicological actions of plant-
Najar, I.A., Sachin, B.S., Sharma, S.C., et al. Modulation of P-