Pricing updated 2019-03-24. Prices are subject to change without notice.
Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization.1,2 Vincristine is exported from cells via the ATP-
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1. Jordan, M.A., Himes, R.H., and Wilson, L. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro Cancer Research 45(6), 2741-2747 (1985).
Towle, M.J., Salvato, K.A., Wels, B.F., et al. Eribulin induces irreversible mitotic blockade: Implications of cell-
van Tellingen, O., Buckle, T., Jonker, J.W., et al. P-
Chan, H.S.L., Haddad, G., Thorner, P.S., et al. P-