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Vincristine (sulfate)

Item № 11764
CAS № 2068-78-2
Purity ≥95%
product image
                (CAS 2068-78-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $29.00 0.00
     10 mg $55.00 0.00
     25 mg $131.00 0.00

Pricing updated 2019-06-15. Prices are subject to change without notice.

Description
Synonyms
  • Kyocristine
  • Lilly 37231
  • Leurocristine
  • Novopharm
  • NSC 67574
  • Oncovin
  • VCR

Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization.1,2 Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.3 Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.4

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Technical Information
Formal Name
22-oxo-vincaleukoblastine sulfate
CAS Number
2068-78-2
Synonyms
  • Kyocristine
  • Lilly 37231
  • Leurocristine
  • Novopharm
  • NSC 67574
  • Oncovin
  • VCR
Molecular Formula
C46H56N4O10 • H2SO4
Formula Weight
923.0
Purity
≥95%
Formulation
A crystalline solid
λmax
221, 259, 296 nm
SMILES
CC[C@]1(O)C[C@@](C[N@@](CC2)C1)([H])C[C@](C(OC)=O)(C3=C(OC)C=C(N(C)[C@]4([H])[C@@]56[C@](N7CC6)([H])[C@](C=CC7)(CC)[C@@H](OC(C)=O)[C@]4(O)C(OC)=O)C5=C3)C8=C2C(C=CC=C9)=C9N8.O=S(O)(O)=O
InChI Code
InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21
InChI Key
AQTQHPDCURKLKT-PNYVAJAMSA-N
Origin
  • Plant/Vinca rosea

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Jordan, M.A., Himes, R.H., and Wilson, L. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro Cancer Research 45(6), 2741-2747 (1985).

2. Towle, M.J., Salvato, K.A., Wels, B.F., et al. Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions Cancer Research 71(2), 496-505 (2011).

3. van Tellingen, O., Buckle, T., Jonker, J.W., et al. P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo British Journal of Cancer 89(9), 1776-1782 (2003).

4. Chan, H.S.L., Haddad, G., Thorner, P.S., et al. P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma New England Journal of Medicine 325(23), 1608-1614 (1991).

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