We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.


Item № 11796
CAS № 524-12-9
Purity ≥98%
product image
                (CAS 524-12-9)
     500 µg $49.00 0.00
     1 mg $83.00 0.00
     5 mg $245.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

  • IKK Inhibitor II

Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM.1,2,3 Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro (IC50 = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (Kd = 2.8 µM).4,5,6 Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARα, lipoprotein lipase, and low-density lipoprotein receptor.7

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
CAS Number
  • IKK Inhibitor II
Molecular Formula
Formula Weight
A crystalline solid
253, 351 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Kobori, M., Yang, Z., Gong, D., et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex Cell Death and Differentiation 11(1), 123-130 (2004).

2. Yuan, F., Chen, J., Sun, P.p., et al. Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB pathway in RAW 264.7 cells Journal of Biomedical Science 20:84, (2013).

3. Alquézar, C., de la Encarnación, A., Moreno, F., et al. Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers J.Psychiatry Neurosci. 41(1), (2016).

4. Kaushik-Basu, N., Bopda-Waffo, A., Talele, T.T., et al. Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors Nucleic Acids Research 35(5), 1482-1496 (2008).

5. Chen, Z., Sun, X., Shen, S., et al. Wedelolactone, a naturally occurring coumestan, enhances interferon-γ signaling through inhibiting STAT1 protein dephosphorylation The Journal of Biological Chemisty 288(20), 14417-14427 (2013).

6. Chen, H., Gao, S., Li, J., et al. Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer Oncotarget 6(15), 13049-13059 (2015).

7. Zhao, Y., Peng, L., Yang, L.c., et al. Wedelolactone regulates lipid metabolism and improves hepatic steatosis partly by AMPK activation and up-regulation of expression of PPARa/LPL and LDLR PLoS One 10(7), (2015).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640