Pricing updated 2019-07-23. Prices are subject to change without notice.
Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM.1,2,3 Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro (IC50 = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (Kd = 2.8 µM).4,5,6 Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARα, lipoprotein lipase, and low-density lipoprotein receptor.7
Warning - this product is not for human or veterinary use.
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Kobori, M., Yang, Z., Gong, D., et al. Wedelolactone suppresses LPS-
Yuan, F., Chen, J., Sun, P.p., et al. Wedelolactone inhibits LPS-
Alquézar, C., de la Encarnación, A., Moreno, F., et al. Progranulin deficiency induces overactivation of WNT5A expression via TNF-
Chen, Z., Sun, X., Shen, S., et al. Wedelolactone, a naturally occurring coumestan, enhances interferon-
Chen, H., Gao, S., Li, J., et al. Wedelolactone disrupts the interaction of EZH2-
Zhao, Y., Peng, L., Yang, L.c., et al. Wedelolactone regulates lipid metabolism and improves hepatic steatosis partly by AMPK activation and up-