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Wedelolactone

Item № 11796
CAS № 524-12-9
Purity ≥98%
product image
                (CAS 524-12-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $49.00 0.00
     1 mg $83.00 0.00
     5 mg $245.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • IKK Inhibitor II

Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM.1,2,3 Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro (IC50 = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (Kd = 2.8 µM).4,5,6 Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARα, lipoprotein lipase, and low-density lipoprotein receptor.7

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Technical Information
Formal Name
1,8,9-trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one
CAS Number
524-12-9
Synonyms
  • IKK Inhibitor II
Molecular Formula
C16H10O7
Formula Weight
314.3
Purity
≥98%
Formulation
A crystalline solid
λmax
253, 351 nm
SMILES
OC1=CC2=C(OC(C(C(O)=CC(OC)=C3)=C3O4)=C2C4=O)C=C1O
InChI Code
InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChI Key
XQDCKJKKMFWXGB-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Kobori, M., Yang, Z., Gong, D., et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex Cell Death and Differentiation 11(1), 123-130 (2004).

2. Yuan, F., Chen, J., Sun, P.p., et al. Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB pathway in RAW 264.7 cells Journal of Biomedical Science 20:84, (2013).

3. Alquézar, C., de la Encarnación, A., Moreno, F., et al. Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers J.Psychiatry Neurosci. 41(1), (2016).

4. Kaushik-Basu, N., Bopda-Waffo, A., Talele, T.T., et al. Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors Nucleic Acids Research 35(5), 1482-1496 (2008).

5. Chen, Z., Sun, X., Shen, S., et al. Wedelolactone, a naturally occurring coumestan, enhances interferon-γ signaling through inhibiting STAT1 protein dephosphorylation The Journal of Biological Chemisty 288(20), 14417-14427 (2013).

6. Chen, H., Gao, S., Li, J., et al. Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer Oncotarget 6(15), 13049-13059 (2015).

7. Zhao, Y., Peng, L., Yang, L.c., et al. Wedelolactone regulates lipid metabolism and improves hepatic steatosis partly by AMPK activation and up-regulation of expression of PPARa/LPL and LDLR PLoS One 10(7), (2015).

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