Pricing updated 2019-07-21. Prices are subject to change without notice.
Artemisinin is an antimalarial agent with anticancer activity.1,2 It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge.3 It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg.1,4 It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).5 Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner.2 It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.
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Akoachere, M., Buchholz, K., Fischer, E., et al. In vitro assessment of methylene blue on chloroquine-
2. Zhu, S., Liu, W., Ke, X., et al. Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma Oncol. Rep. 32(3), 1094-1100 (2014).
Ooko, E., Saeed, M.E.M., Kadioglu, O., et al. Artemisinin derivatives induce iron-
Robert, A., Benoit-
5. Chawira, A.N., Warhurst, D.C., Robinson, B.L., et al. The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice Trans. R. Soc. Trop. Med. Hyg. 81(4), 554-558 (1987).