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GQ-16

Item № 11908
CAS № 870554-67-9
Purity ≥98%
product image
                (CAS 870554-67-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $25.00 0.00
     10 mg $48.00 0.00
     50 mg $200.00 0.00
     100 mg $350.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description

Full activation of peroxisome proliferator-activated receptor γ (PPARγ), e.g., using thiazolidinediones, effectively treats insulin resistance and type 2 diabetes but also commonly promotes weight gain, hyperphagia, and edema.1 GQ-16 is a partial agonist for PPARγ (Ki = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone.1 Like rosiglitazone, GQ-16 reverses high fat diet-mediated impairments in insulin signaling.1 However, GQ-16 does not induce weight gain, hyperphagia, or edema. GQ-16 does not activate PPARα, PPARβ/δ, or RXRα.1

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Technical Information
Formal Name
5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione
CAS Number
870554-67-9
Molecular Formula
C19H16BrNO3S
Formula Weight
418.3
Purity
≥98%
Formulation
A crystalline solid
λmax
213, 308, 359 nm
SMILES
BrC1=CC(/C=C2C(N(CC3=CC=C(C)C=C3)C(S/2)=O)=O)=C(OC)C=C1
InChI Code
InChI=1S/C19H16BrNO3S/c1-12-3-5-13(6-4-12)11-21-18(22)17(25-19(21)23)10-14-9-15(20)7-8-16(14)24-2/h3-10H,11H2,1-2H3/b17-10-
InChI Key
AMLZLORVKZAHOH-YVLHZVERSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Amato, A.A., Rajagopalan, S., Lin, J.Z., et al. GQ-16, a novel PPARγ ligand, promotes insulin sensitization without weight gain The Journal of Biological Chemisty 1-20 (2012).

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