Pricing updated 2019-07-21. Prices are subject to change without notice.
(+)-Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT1), an enzyme that combines fatty acyl-CoAs with carnitine for transport into the mitochondria for β-oxidation.1,2 It inhibits fatty acid oxidation in hepatocytes in vitro (IC50s = 0.1, 1, and 10 µM for human, guinea pig, and rat hepatocytes, respectively), and it shifts the carbon source for the TCA cycle to glucose.3,4 It also inhibits cholesterol synthesis from acetate in hepatocytes upstream of mevalonate.5 (+)-Etomoxir also decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES (Item No. 19284) or UK 5099 (Item No. 16980).6
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Portilla, D., Dai, G., Peters, J.M., et al. Etomoxir-
Lopaschuk, G.D., Wall, S.R., Olley, P.M., et al. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-
Agius, L., Peak, M., and Sherratt, H.S.A. Differences between human, rat and guinea pig hepatocyte cultures. A comparative study of their rates of β-
5. Agius, L., Meredith, E.J., and Sherratt, H.S.A. Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes Biochem. Pharmacol. 42(9), 1717-1720 (1991).
6. Vacanti, N.M., Divakaruni, A.S., Green, C.R., et al. Regulation of substrate utilization by the mitochondrial pyruvate carrier Mol. Cell 56(3), 425-435 (2014).
Singh, S.R., Zeng, X., Zhao, J., et al. The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila Nature 538(7623), 109-113 (2016).