(+)-Etomoxir (sodium salt) (CAS 828934-41-4) | Cayman Chemical
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(+)-Etomoxir (sodium salt)

Item № 11969
CAS № 828934-41-4
Purity ≥98%
product image
                (CAS 828934-41-4)
     5 mg $85.00 0.00
     10 mg $128.00 0.00
     25 mg $298.00 0.00
     50 mg $510.00 0.00

Pricing updated 2018-11-16. Prices are subject to change without notice.

  • (R)-(+)-Etomoxir

(+)-Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1, a mitochondrial enzyme involved in fatty acid β-oxidation (IC50 = 5-20 nM in rat liver).1,2 By regulating fatty acid oxidation, (+)-etomoxir has the potential to affect ketogenesis, cholesterol synthesis, and gluconeogenesis.3,4 (+)-Etomoxir has also been identified as a direct agonist of PPARα.1,5

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Technical Information
Formal Name
(2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid monosodium salt
CAS Number
  • (R)-(+)-Etomoxir
Molecular Formula
C15H18ClO4 • Na
Formula Weight
A crystalline solid
229,282 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Portilla, D., Dai, G., Peters, J.M., et al. Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure Am.J.Physiol.Renal.Physiol. 278(4), F667-F675 (2000).

2. Lopaschuk, G.D., Wall, S.R., Olley, P.M., et al. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine Circulation Research 63(6), 1036-1043 (1988).

3. Luiken, J.J., Niessen, H.E., Coort, S.L., et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates Biochemistry Journal 419(2), 447-455 (2009).

4. Xu, F.Y., Taylor, W.A., Hurd, J.A., et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells Journal of Lipid Research 44(2), 415-423 (2003).

5. Skorin, C., Necochea, C., Johow, V., et al. Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes Biochemistry Journal 281 (Pt 2), 561-567 (1992).

Product Citations

Singh, S.R., Zeng, X., Zhao, J., et al. The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila Nature 538(7623), 109-113 (2016).

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