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SB-431542

Item № 13031
CAS № 301836-41-9
Purity ≥98%
product image
                (CAS 301836-41-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $25.00 0.00
     5 mg $75.00 0.00
     10 mg $105.00 0.00
     25 mg $225.00 0.00

Pricing updated 2019-05-25. Prices are subject to change without notice.

Description

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM)1. It is a less potent antagonist of ALK4 (IC50 = 140 nM)2 and ALK7.3 It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3 SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3 Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5

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Technical Information
Formal Name
4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide
CAS Number
301836-41-9
Molecular Formula
C22H16N4O3
Formula Weight
384.4
Purity
≥98%
Formulation
A crystalline solid
λmax
329 nm
SMILES
NC(=O)c1ccc(cc1)c1[nH]c(c2ccccn2)c(n1)c1ccc2OCOc2c1
InChI Code
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChI Key
FHYUGAJXYORMHI-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Callahan, J.F., Burgess, J.L., Fornwald, J.A., et al. Identification of novel inhibitors of the transforming growth factor ß1 (TGF-ß1) type 1 receptor (ALK5) Journal of Medicinal Chemistry 45(5), 999-1001 (2002).

2. Laping, N.J., Grygielko, E., Mathur, A., et al. Inhibition of Transforming Growth Factor (TGF)-ß1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-ß Type I Receptor Kinase Activity: SB-431542 Molecular Pharmacology 62(1), 58-64 (2002).

3. Inman, G.J., Nicolás, F.J., Callahan, J.F., et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 Molecular Pharmacology 62(1), 65-74 (2002).

4. James, D., Levine, A.J., Besser, D., et al. TGFß/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells Development 132, 1273-1282 (2005).

5. Chambers, S.M., Fasano, C.A., Papapetrou, E.P., et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling Nature Biotechnology 27(3), 275-280 (2009).

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