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Item № 13031
CAS № 301836-41-9
Purity ≥98%
product image
                (CAS 301836-41-9)
     1 mg $25.00 0.00
     5 mg $75.00 0.00
     10 mg $105.00 0.00
     25 mg $225.00 0.00

Pricing updated 2019-05-25. Prices are subject to change without notice.


SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM)1. It is a less potent antagonist of ALK4 (IC50 = 140 nM)2 and ALK7.3 It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3 SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3 Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5

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Technical Information
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CAS Number
Molecular Formula
Formula Weight
A crystalline solid
329 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

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Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Callahan, J.F., Burgess, J.L., Fornwald, J.A., et al. Identification of novel inhibitors of the transforming growth factor ß1 (TGF-ß1) type 1 receptor (ALK5) Journal of Medicinal Chemistry 45(5), 999-1001 (2002).

2. Laping, N.J., Grygielko, E., Mathur, A., et al. Inhibition of Transforming Growth Factor (TGF)-ß1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-ß Type I Receptor Kinase Activity: SB-431542 Molecular Pharmacology 62(1), 58-64 (2002).

3. Inman, G.J., Nicolás, F.J., Callahan, J.F., et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 Molecular Pharmacology 62(1), 65-74 (2002).

4. James, D., Levine, A.J., Besser, D., et al. TGFß/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells Development 132, 1273-1282 (2005).

5. Chambers, S.M., Fasano, C.A., Papapetrou, E.P., et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling Nature Biotechnology 27(3), 275-280 (2009).

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