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Metformin (hydrochloride)

Item № 13118
CAS № 1115-70-4
Purity ≥98%
product image
                (CAS 1115-70-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 g $18.00 0.00
     5 g $27.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • 1,1-Dimethylbiguanide hydrochloride

Metformin is a biguanide with diverse biological activities.1,2,3,4 Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice.2 It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day.4 It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD).5 Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I.3 Formulations containing metformin have been used in the treatment of type 2 diabetes.

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Technical Information
Formal Name
N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride
CAS Number
1115-70-4
Synonyms
  • 1,1-Dimethylbiguanide hydrochloride
Molecular Formula
C4H11N5 • HCl
Formula Weight
165.6
Purity
≥98%
Formulation
A crystalline solid
λmax
237 nm
SMILES
CN(C)C(NC(N)=N)=N.Cl
InChI Code
InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChI Key
OETHQSJEHLVLGH-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Viollet, B., Guigas, B., Garcia, N.S., et al. Cellular and molecular mechanisms of metformin: An overview Clin.Sci.(Lond) 122(6), 253-270 (2012).

2. Shaw, R.J., Lamia, K.A., Vasquez, D., et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310, 1642-1646 (2005).

3. Wheaton, W.W., Weinberg, S.E., Hamanaka, R.B., et al. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis Elife 3:e02242, (2014).

4. Kim, E.K., Lee, S.H., Jhun, J.Y., et al. Metformin prevents fatty liver and improves balance of white/brown adipose in an obesity mouse model by inducing FGF21. Mediators Inflamm. 5813030, (2016).

5. Lin, M.-J., Dai, W., Scott, M.J., et al. Metformin improves nonalcoholic fatty liver disease in obese mice via down-regulation of apolipoprotein A5 as part of the AMPK/LXRα signaling pathway Oncotarget 8\(65), 108802-108809 (2017).

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