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Imatinib (mesylate)

Item № 13139
CAS № 220127-57-1
Purity ≥98%
product image
                (CAS 220127-57-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     25 mg $25.00 0.00
     50 mg $48.00 0.00
     100 mg $80.00 0.00
     500 mg $350.00 0.00

Pricing updated 2019-06-26. Prices are subject to change without notice.

Description
Synonyms
  • CGP57148B
  • STI-571

Imatinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit.1 It inhibits ligand-stimulated autophosphorylation of PDGFR and c-Kit (IC50s = ~0.3 and ~0.1 μM, respectively).1,2 Imatinib inhibits the proliferation of Bcr-Abl-dependent R10(–) cells (IC50s = ~35-40 nM) and HMC-1 cells expressing constitutively active c-Kit in a concentration-dependent manner.1,3 It prolongs survival in a mouse model of chronic myeloid leukemia when administered at a dose of 100 mg/kg twice per day.4 Formulations containing imatinib have been used in the treatment of various cancers.

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Technical Information
Formal Name
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide, monomethanesulfonate
CAS Number
220127-57-1
Synonyms
  • CGP57148B
  • STI-571
Molecular Formula
C29H31N7O • CH4SO3
Formula Weight
589.7
Purity
≥98%
Formulation
A crystalline solid
λmax
238, 271 nm
SMILES
CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(C)c(c1)Nc1nccc(n1)c1cccnc1CS(=O)(=O)O
InChI Code
InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
InChI Key
YLMAHDNUQAMNNX-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Heinrich, M.C., Griffith, D.J., Druker, B.J., et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor Blood 96(3), 925-932 (2000).

2. Buchdunger, E., Zimmermann, J., Mett, H., et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative Cancer Res. 56(1), 100-104 (1996).

3. Wolff, N.C., Veach, D.R., Tong, W.P., et al. PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia Blood 105(10), 3995-4003 (2005).

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