Pricing updated 2019-07-17. Prices are subject to change without notice.
(–)-Sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 18 nM).1 It is selective for DPP-4 over DPP-8 (IC50 = 48 µM) as well as several other peptidases, including DPP-9, DPP-2, and amino peptidase P.1,2 (–)-Sitagliptin improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet fed rats as well as ob/ob and high-fat diet fed mice.3 It also reduces hyperglycemia in mice fed a high-fat diet with diabetes induced by streptozotocin (Item No. 13104). Formulations containing (–)-sitagliptin have been used in the treatment of type 2 diabetes mellitus.
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Biftu, T., Feng, D., Qian, X., et al. (3R)-
Kim, D., Kowalchick, J.E., Edmondson, S.D., et al. Triazolopiperazine-
Ahrén, B. DPP-