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AM3102

Item № 13452
CAS № 213182-22-0
Purity ≥98%
product image
                (CAS 213182-22-0)

Formulation:  A crystalline solid

SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $35.00 0.00
     10 mg $67.00 0.00
     50 mg $280.00 0.00
     100 mg $490.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • KDS-5104

Oleoyl ethanolamide (OEA) is an endogenous agonist for proliferator-activated receptor α (PPARα) that suppresses food intake, promotes lipolysis, and reduces weight gain in rodents. The biological effects of OEA are terminated by fatty-acid amide hydrolase and N-acylethanolamine-hydrolyzing acid amidase. AM3102 is an OEA analog that stimulates PPARα transcriptional activity with an EC50 value of 100 nM and prolongs feeding latency in rodents with an ED50 value of 2.4 mg/kg.1 It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARα and reducing food intake in free-feeding rats.1,2 AM3102 demonstrates weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 33 and 26 µM, respectively.3

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Technical Information
Formal Name
N-[(1R)-2-hydroxy-1-methylethyl-9Z-octadecenamide
CAS Number
213182-22-0
Synonyms
  • KDS-5104
Molecular Formula
C21H41NO2
Formula Weight
339.6
Purity
≥98%
Formulation
A crystalline solid
SMILES
OC[C@@H](C)NC(CCCCCCC/C=C\CCCCCCCC)=O
InChI Code
InChI=1S/C21H41NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21(24)22-20(2)19-23/h10-11,20,23H,3-9,12-19H2,1-2H3,(H,22,24)/b11-10-/t20-/m1/s1
InChI Key
IPVYNYWIRWMRHH-JPMGXVIASA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Astarita, G., Di Giacomo, B., Gaetani, S., et al. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties Journal of Pharmacology and Experimental Therapeutics 318(2), 563-570 (2006).

2. Wang, J., and Ueda, N. Role of the endocannabinoid system in metabolic control Current Opinion in Nephrology and Hypertension 17, 1-10 (2008).

3. Lin, S., Khanolkar, A.D., Fan, P., et al. Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability Journal of Medicinal Chemistry 41, 5353-5361 (1998).

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