Pricing updated 2019-07-17. Prices are subject to change without notice.
Sterol regulatory element binding proteins (SREBPs) are transcription factors that have pivotal roles in lipogenesis and fat metabolism.1 The activation of SREBPs requires escort to the Golgi by SREBP cleavage-
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1. Horton, J.D., Goldstein, J.L., and Brown, M.S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver Journal of Clinical Investigation 109, 1125-1131 (2002).
2. Raghow, R., Yellaturu, C., Deng, X., et al. SREBPs: The crossroad of physiological and pathological lipid homeostasis Trends in Endocrinology and Metabolism 19(2), 65-73 (2008).
Kamisuki, S., Mao, Q., Abu-
Kamisuki, S., Shirakawa, T., Kugimiya, A., et al. Synthesis and evaluation of diaryl thiazole derivatives that inhibit activation of sterol regulatory element-
5. Choi, Y., Kawazoe, Y., Murakami, K., et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds The Journal of Biological Chemisty 278(9), 7320-7324 (2003).
Uttarwar, L., Gao, B., Ingram, A.J., et al. SREBP-