Toll-Like Receptor 1 Polyclonal Antibody | Cayman Chemical
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Toll-Like Receptor 1 Polyclonal Antibody

Item № 13582
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     1 ea $265.00 0.00

Pricing updated 2018-11-19. Prices are subject to change without notice.

  • TLR1

The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.1 The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.2 Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. In mice, TLR1 interacts with TLR2 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.

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Technical Information
  • TLR1
synthetic peptide from human TLR1 amino acids 400-450
0.1 mg of protein G-purified in 0.2 ml PBS containing 0.05% BSA and 0.05% sodium azide
WB and FC (intracellular and cell surface)
Species Reactivity
  • (+) Human TLR1
  • (+) Mouse TLR1
  • (+) Rat TLR1

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 1 year
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References & Product Citations
Product Description References

1. Srivastava, M.D., and Srivastava, B.I.S. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line Leukemia Research 7, 813-820 (2005).

2. Gibson, F.C., Hong, C., Chou, H.H., et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice Circulation 109, 2801-2806 (2004).

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