Pricing updated 2018-03-20. Prices are subject to change without notice.
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin.1 ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively).2 It has no effect on several other kinases, including Cdk1, Cdk2, Cdk4, Plk1, CHK1, KDR2, and FAK (IC50 > 10 µM).3 ZM 447439 has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis.3,4 Moreover, ZM 447439 selectively inhibits proliferating cells rather than non-
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1. Carmena, M.,Ruchaud, S., and Earnshaw, W.C. Making the Auroras glow: Regulation of Aurora A and B kinase function by interacting proteins. Current Opinion in Cell Biology 21(6), 796-805 (2009).
Girdler, F.,Gascoigne, K.E.,Eyers, P.A., et al. Validating Aurora B as an anti-
Ditchfield, C.,Johnson, V.L.,Tighe, A., et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-
Gadea, B.B., and Ruderman, J.V. Aurora kinase inhibitor ZM447439 blocks chromosome-