ZM 447439 (CAS 331771-20-1) | Cayman Chemical

ZM 447439

Item № 13601
CAS № 331771-20-1
Purity ≥98%
     5 mg $48.00 0.00
     10 mg $86.00 0.00
     50 mg $288.00 0.00

Pricing updated 2018-03-20. Prices are subject to change without notice.


The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin.1 ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively).2 It has no effect on several other kinases, including Cdk1, Cdk2, Cdk4, Plk1, CHK1, KDR2, and FAK (IC50 > 10 µM).3 ZM 447439 has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis.3,4 Moreover, ZM 447439 selectively inhibits proliferating cells rather than non-dividing cells, suggesting its potential in cancer therapy.2

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Technical Information
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Molecular Formula
Formula Weight
A crystalline solid
226, 252, 343 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

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Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Carmena, M.,Ruchaud, S., and Earnshaw, W.C. Making the Auroras glow: Regulation of Aurora A and B kinase function by interacting proteins. Current Opinion in Cell Biology 21(6), 796-805 (2009).

2. Girdler, F.,Gascoigne, K.E.,Eyers, P.A., et al. Validating Aurora B as an anti-cancer drug target. Journal of Cell Science 119, 3664-3675 (2006).

3. Ditchfield, C.,Johnson, V.L.,Tighe, A., et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. Journal of Cell Biology 161(2), 267-280 (2003).

4. Gadea, B.B., and Ruderman, J.V. Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts. Molecular Biology of the Cell 16, 1305-1318 (2005).

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