Pricing updated 2019-02-20. Prices are subject to change without notice.
DOT1L is a protein methyltransferase (PMT). It is the only enzyme known to methylate histone 3 at lysine 79 (H3K79), where it catalyzes mono-
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Bernt, K.M., and Armstrong, S.A. A role for DOT1L in MLL-
2. Nguyen, A.T., He, J., Taranova, O., et al. Essential role of DOT1L in maintaining normal adult hematopoiesis Cell Research 21(9), 1370-1373 (2011).
3. Yu, W., Chory, E.J., Wernimont, A.K., et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors Nat.Commun. 3, 1-12 (2012).