We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.


Item № 14007
CAS № 38966-21-1
Purity ≥98%
product image
                (CAS 38966-21-1)
     1 mg $68.00 0.00
     5 mg $220.00 0.00
     25 mg $765.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

  • ICI 69653
  • NSC 234714

(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex.1 In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.2,3,4 Aphidicolin can be used, at 3 μM, to arrest cells in G1/S phase or to increase gene amplification frequency.5,6

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
CAS Number
  • ICI 69653
  • NSC 234714
Molecular Formula
Formula Weight
A solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Bucknall, R.A., Moores, H., Simms, R., et al. Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola Antimicrobial Agents and Chemotherapy 4(3), 294-298 (1973).

2. Oguro, M., Suzuki-Hori, C., Nagano, H., et al. The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase α Eur. J. Biochem. 97(2), 603-607 (1979).

3. Krokan, H., Wist, E., and Krokan, R.H. Aphidicolin inhibits DNA synthesis by DNA polymerase α and isolated nuclei by a similar mechanism Nucleic Acids Research 9(18), 4709-4719 (1981).

4. Cheng, C.H., and Kuchta, R.D. DNA polymerase ε: Aphidicolin inhibition and the relationship between polymerase and exonuclease activity Biochemistry 32(33), 8568-8574 (1993).

5. Kota, K.P., Benko, J.G., Mudhasani, R., et al. High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection Viruses 4(10), 1865-1877 (2012).

6. Yin, D.X., and Schimke, R.T. Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment Proc. Natl. Acad. Sci. USA 93(8), 3394-3398 (1996).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640