We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.


Item № 14015
CAS № 6894-43-5
Purity ≥98%
product image
                (CAS 6894-43-5)
     5 mg $52.00 0.00
     10 mg $99.00 0.00
     25 mg $234.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.


Kahweol is a natural diterpene that is isolated from coffee beans.1 It increases glutathione S-transferase activity in the gut mucosa of mice and, with the diterpene cafestol, induces glutathione S-transferase expression in rat livers.1,2 Kahweol has anti-inflammatory effects in RAW macrophages, inhibiting LPS-induced nitric oxide and prostaglandin E2 production (IC50 = 54 and 23 μM, respectively).3 Kahweol also is antiangiogenic, blocking the proliferation of endothelial cells (IC50 = 50 μM) and inhibiting endothelial migration, invasion, and tube formation.4 Kahweol is easily oxidized in the presence of air.1

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
CAS Number
Molecular Formula
Formula Weight
A crystalline sold
204, 289 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Lam, L.K.T., Sparnins, V.L., and Wattenberg, L.W. Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse Cancer Research 42, 1193-1198 (1982).

2. Cavin, C., Holzhäuser, D., Constable, A., et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism Carcinogenesis 19(8), 1369-1375 (1998).

3. Shen, T., Park, Y.C., Kim, S.H., et al. Nuclear factor-κB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene Biological and Pharmaceutical Bullentin 33(7), 1159-1164 (2010).

4. Cárdenas, C., Quesada, A.R., and Medina, M.A. Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene PLoS One 6(8), (2011).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640