MT-45 (hydrochloride) (CAS 57314-55-3) | Cayman Chemical
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MT-45 (hydrochloride)

Item № 14082
CAS № 57314-55-3
Purity ≥98%

Formulation:  A neat solid

     1 mg $65.00 0.00
     5 mg $124.00 0.00
     10 mg $195.00 0.00

Pricing updated 2018-06-23. Prices are subject to change without notice.

  • This product has been manufactured and tested to meet ISO17025:2005 and Guide 34:2009 guidelines
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing
  • I-C6
  • NSC 299236

MT-45 is a piperazine derivative with potent analgesic activity comparable to morphine (Item No. ISO60147) despite being structurally unrelated to most other opioids.1 In particular, the S-(+)-enantiomer of MT-45 (Item No. 15128) displays analgesic potency similar to that of morphine (ED50s = 0.35 and 0.4 μg/kg, i.v., respectively in Haffner’s mouse tail-pinch method), whereas the R-(−)-isomer (Item No. 15127) displays comparatively weak activity (ED50 = 2 μg/kg, i.v.).2 Furthermore, the analgesic activity of the racemate (±) is reported to be more potent (ED50 = 0.12 μg/kg, i.v.) than its enantiomorphic pairs.2 MT-45 has been used as a lead compound to develop a large group of potent opioid drugs with agonist or antagonist activities particular to the various opioid receptor subtypes.3 This product is intended for forensic and research applications.

This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support

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Technical Information
Formal Name
1-cyclohexyl-4-(1,2-diphenylethyl)-piperazine, dihydrochloride
CAS Number
  • I-C6
  • NSC 299236
Molecular Formula
C24H32N2 • 2HCl
Formula Weight
A neat solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 1 year
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References & Product Citations
Product Description References

1. Natsuka, K., Nakamura, H., Uno, H., et al. Studies on 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives and their analgesic activities. 1. Journal of Medicinal Chemistry 18(12), 1240-1244 (1975).

2. Fujimura, H., Tsurumi, K., Nozaki, M., et al. Analgesic activity and opiate receptor binding of 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine. Japanese Journal of Pharmacology 28(3), 505-506 (1978).

3. Natsuka, K., Nakamura, H., Nishikawa, Y., et al. Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity. Journal of Medicinal Chemistry 30(10), 1779-1787 (1987).

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