We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

ZLN005

Item № 14121
CAS № 49671-76-3
Purity ≥98%
product image
                (CAS 49671-76-3)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $29.00 0.00
     10 mg $46.00 0.00
     25 mg $102.00 0.00
     50 mg $168.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis.1 ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM.2 Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.2

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole
CAS Number
49671-76-3
Molecular Formula
C17H18N2
Formula Weight
250.3
Purity
≥98%
Formulation
A crystalline solid
λmax
243, 305, 319 nm
SMILES
CC(C)(C)C(C=C1)=CC=C1C2=NC3=CC=CC=C3N2
InChI Code
InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)
InChI Key
LQUNNCQSFFKSSK-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Lin, J., Handschin, C., and Spiegleman, B.M. Metabolic control through the PGC-1 family of transcription coactivators Cell Metabolism 1, 361-370 (2005).

2. Zhang, L.N., Zhou, H.Y., Fu, Y.Y., et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice Diabetes 62(4), 1297-1307 (2013).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640