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1-EBIO

Item № 14575
CAS № 10045-45-1
Purity ≥98%
product image
                (CAS 10045-45-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $25.00 0.00
     10 mg $40.00 0.00
     50 mg $158.00 0.00
     100 mg $290.00 0.00

Pricing updated 2019-04-23. Prices are subject to change without notice.

Description
Synonyms
  • 1-Ethylbenzimidazolinone

1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells).1 This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.2 In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.3 It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 µM).4 1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.5,6

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Technical Information
Formal Name
1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
CAS Number
10045-45-1
Synonyms
  • 1-Ethylbenzimidazolinone
Molecular Formula
C9H10N2O
Formula Weight
162.2
Purity
≥98%
Formulation
A crystalline solid
λmax
229, 285 nm
SMILES
O=C(N1CC)NC2=C1C=CC=C2
InChI Code
InChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
InChI Key
CXUCKELNYMZTRT-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Devor, D.C., Singh, A.K., Frizzell, R.A., et al. Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel American Journal of Physiology 271, L775-L784 (1996).

2. Cuthbert, A.W., Hickman, M.E., Thorn, P., et al. Activation of Ca2+- and cAMP-sensitive K+ channels in murine colonic epithelia by 1-ethyl-2-benzimidazolone American Journal of Physiology.Endocrinology and Metabolism 277(1), C111-C120 (1999).

3. MacVinish, L.J., Hickman, M.E., Mufti, D.A., et al. Importance of basolateral K+ conductance in maintaining Cl- secretion in murine nasal and colonic epithelia Journal of Physiology 510(1), 237-247 (1998).

4. Jensen, B.S., Strobæk, D., Christophersen, P., et al. Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel American Journal of Physiology 275(3), C848-C856 (1998).

5. Gao, Z., Todorov, B., Barrett, C.F., et al. Cerebellar ataxia by enhanced Cav2.1 currents is alleviated by Ca+2-dependent K+-channel activators in CacnalaS218L mutant mice Journal of Neuroscience 32(44), 15533-15546 (2012).

6. Maiz, J., Karakossian, M.H., Pakaprot, N., et al. Prolonging the postcomplex spike pause speeds eyeblink conditioning Proceedings of the National Academy of Sciences of the United States of America 109(41), 16726-16730 (2012).

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