We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

(R)-PFI-2 (hydrochloride)

Item № 14678
CAS № 1627607-87-7
Purity ≥95%
product image
                (CAS 1627607-87-7)
     1 mg $39.00 0.00
     5 mg $127.00 0.00
     10 mg $234.00 0.00
     25 mg $536.00 0.00

Pricing updated 2019-05-26. Prices are subject to change without notice.

  • (-)-PFI-2

SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the transcription factor TAF10.1,2 (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases.3 Its enantiomer, (S)-PFI-2 (Item No. 18119), is 500-fold less active (IC50 = 1 µM).3 See the Structural Genomics Consortium (SGC) website for more information.

Recommended Products

Related Products
View Related Product Categories
View Screening Libraries with (R)-PFI-2 (hydrochloride)
Technical Information
Formal Name
8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide, monohydrochloride
CAS Number
  • (-)-PFI-2
Molecular Formula
C23H25F4N3O3S • HCl
Formula Weight
A crystalline solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Download SGC Epigenetic Chemical Probe Guide

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Couture, J.F., Collazo, E., Hauk, G., et al. Structural basis for the methylation site specificity of SET7/9 Nature Structural & Molecular Biology 13(2), 140-146 (2006).

2. Kurash, J.K., Lei, H., Shen, Q., et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo Molecular Cell 29, 392-400 (2008).

3. Barsyte-Lovejoy, D., Li, F., Oudhoff, M.J., et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells Proceedings of the National Academy of Sciences of the United States of America 111(35), 12853-12858 (2014).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640