CysLT1 Receptor Polyclonal FITC Antibody | Cayman Chemical
We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

CysLT1 Receptor Polyclonal FITC Antibody

Item № 14713
     500 µl $289.00 0.00

Pricing updated 2018-11-15. Prices are subject to change without notice.

  • Cysteinyl Leukotriene Receptor 1

The cysteinyl leukotrienes (CysLTs; LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma.1,2,3,4 LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2.1 Cloning of the human CysLT1 receptor reveals it is a 337 amino acid protein with a calculated molecular mass of 38,549.5 The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTD4 >> LTC4 = LTE4 >> LTB4.5 The mRNA for the human CysLT1 receptor is expressed in spleen and peripheral blood leukocytes with smaller amounts in lung, placenta, and small intestine. Immunohistochemical studies reveal the receptor is expressed on eosinophils, mast cells, macrophages, neutrophils, and vascular endothelial cells in the nasal mucosa.6

Recommended Products

Related Products
View Related Product Categories
Technical Information
  • Cysteinyl Leukotriene Receptor 1
Synthetic peptide from the C-terminal region of CysLT1 receptor
500 µl peptide affinity-purified, fluorescein-labeled polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Species Reactivity
  • (+) Human CysLT1
  • (+) Mouse CysLT1
UniProt Accession №

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 1 year
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Gorenne, I., Norel, X., and Brink, C. Cysteinyl leukotriene receptors in the human lung: What’s new? Trends in Pharamacological Sciences 17, 342-343 (1996).

2. Dahlén, S.E., Hansson, G., Hedqvist, P., et al. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4 Proceedings of the National Academy of Sciences of the United States of America 80, 1712-1716 (1983).

3. Busse, W.W. The role of leukotrienes in asthma and allergic rhinitis Clinical and Experimental Allergy 26, 868-879 (1996).

4. Hedqvist, P., Dahlén, S.E., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4 Acta Physiologica Scandinavica 110, 331-333 (1980).

5. Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor Nature 399, 789-793 (1999).

6. Shirasaki, H., Kanaizumi, E., Watanabe, K., et al. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa Clinical and Experimental Allergy 32, 1007-1012 (2002).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640