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AMPK activator

Item № 14741
CAS № 849727-81-7
Purity ≥95%
product image
                (CAS 849727-81-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $45.00 0.00
     5 mg $158.00 0.00
     10 mg $270.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • D942

AMPK activator is an indirect activator of AMP-activated protein kinase, AMPK (EC50 = 11.7 μM).1 It is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels.1 AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, a known target of AMPK.1 AMPK activator also decreases blood glucose concentrations in female Zucker diabetic rats, demonstrating its utility in whole animals.1 At 50 μM, it inhibits the growth of multiple myeloma cells.2 AMPK activator induces phosphorylation of raptor in PC3 prostate cancer cells, down-regulating mTORC1 signaling and reducing survivin expression.3

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Technical Information
Formal Name
5-[3-[4-[2-(4-fluorophenyl)ethoxy]phenyl]propyl]-2-furancarboxylic acid
CAS Number
849727-81-7
Synonyms
  • D942
Molecular Formula
C22H21FO4
Formula Weight
368.4
Purity
≥95%
Formulation
A crystalline solid
λmax
225, 263 nm
SMILES
FC1=CC=C(CCOC2=CC=C(CCCC3=CC=C(C(O)=O)O3)C=C2)C=C1
InChI Code
InChI=1S/C22H21FO4/c23-18-8-4-17(5-9-18)14-15-26-19-10-6-16(7-11-19)2-1-3-20-12-13-21(27-20)22(24)25/h4-13H,1-3,14-15H2,(H,24,25)
InChI Key
MPLLLQUZNJSVTK-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Kosaka, T., Okuyama, R., Sun, W., et al. Identification of molecular target of AMP-activated protein kinase activator by affinity purification and mass spectrometry Analytical Chemistry 77(7), 2050-2055 (2005).

2. Baumann, P., Mandl-Weber, S., Emmerich, B., et al. Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells Experimental Cell Research 313(16), 3592-3603 (2007).

3. Roca, H., Varsos, Z.S., and Pienta, K.J. CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells Neoplasia 11(12), 1309-1317 (2009).

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