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Oxymatrine

Item № 14915
CAS № 16837-52-8
Purity ≥98%
product image
                (CAS 16837-52-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     50 mg $39.00 0.00
     100 mg $66.00 0.00
     500 mg $137.00 0.00
     1 g $195.00 0.00

Pricing updated 2019-06-26. Prices are subject to change without notice.

Description
Synonyms
  • Matrine 1-oxide

Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine.1 It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine.2,3 Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling.4,5 This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-κB.1,6

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Technical Information
Formal Name
(4R,7aS,13aR,13bR,13cS)-dodecahydro-4-oxide-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
CAS Number
16837-52-8
Synonyms
  • Matrine 1-oxide
Molecular Formula
C15H24N2O2
Formula Weight
264.4
Purity
≥98%
Formulation
A crystalline solid
SMILES
O=C1N2[C@@](CCC1)([H])[C@]3([H])[C@@]4([H])[N+](CCC[C@@]4([H])C2)([O-])CCC3
InChI Code
InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1
InChI Key
XVPBINOPNYFXID-LHDUFFHYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Ling, Q., Xu, X., Wei, X., et al. Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c J.Exp.Clin.Cancer Res. 30, 66 (2011).

2. Cui, X., Wang, Y., Kokudo, N., et al. Traditional Chinese medicine and related active compounds against hepatitis B virus infection Biosci.Trends 4(2), 39-47 (2010).

3. Ma, Z.J., Li, Q., Wang, J.B., et al. Combining oxymatrine or matrine with lamivudine increased its antireplication effect against the hepatitis B virus in vitro Evidence-Based Complementary and alternative Medicine 2013, 186573 (2013).

4. Chai, N.L., Fu, Q., Shi, H., et al. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells World Journal of Gastroenterology 18(31), 4199-4206 (2012).

5. Wu, X.L., Zeng, W.Z., Jiang, M.D., et al. Effect of oxymatrine on the TGβSmad signaling pathway in rats with CCl4-induced hepatic fibrosis World Journal of Gastroenterology 14(13), 2100-2105 (2008).

6. Guzman, J.R., Koo, J.S., Goldsmith, J.R., et al. Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation Sci.Rep. 3, 1629 (2013).

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