Pricing updated 2019-07-23. Prices are subject to change without notice.
PPARβ/δ is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers.1,2,3,4 GSK3787 is an irreversible antagonist of PPARβ/δ (pIC50 = 6.6) with no measurable affinity for PPARα or PPARγ (pIC50 >5).5 At 1μM, it inhibits the expression of PPARβ/δ-
Warning - this product is not for human or veterinary use.
View the Cayman Structure Database for chemical structure definitions for many Cayman products
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
Michalik, L., Desvergne, B., and Wahli, W. Peroxisome-
Girroir, E.E., Hollingshead, H.E., Billin, A.N., et al. Peroxisome proliferator-
Peters, J.M., Foreman, J.E., and Gonzalez, F.J. Dissecting the role of peroxisome proliferator-
4. Elikkottil, J., Kohli, D.R., and Gupta, K. Antitumor activity of a PPARδ antagonist Cancer Biol. Ther. 8(13), 1262-1264 (2009).
Shearer, B.G., Wiethe, R.W., Ashe, A., et al. Identification and characterization of 4-
Palkar, P.S., Borland, M.G., Naruhn, S., et al. Cellular and pharmacological selectivity of the peroxisome proliferator-