SF1670 (CAS 345630-40-2) | Cayman Chemical
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SF1670

Item № 15368
CAS № 345630-40-2
Purity ≥98%
product image
                (CAS 345630-40-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $49.00 0.00
     5 mg $115.00 0.00

Pricing updated 2018-05-28. Prices are subject to change without notice.

Description

Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids including Akt and phosphatidylinositol 3,4,5-trisphosphate (PIP3). SF1670 specifically binds to the active site of PTEN inhibiting its activity with an IC50 value of 2 μM.1,2 At nanomolar concentrations it increases cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes.2,3 Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.3

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Technical Information
Formal Name
N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
CAS Number
345630-40-2
Molecular Formula
C19H17NO3
Formula Weight
307.4
Purity
≥98%
Formulation
A dark purple solid
λmax
213, 279, 448 nm
SMILES
O=C1C2=CC=CC=C2C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C1=O
InChI Code
InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
InChI Key
VZQDDSYKVYARDW-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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References & Product Citations
Product Description References

1. Garlich, J.R., Durden, D.L., Georgiadis, T.M., et al. PTEN inhibitors. PCT/US2005/011626, 1-85 (2005).

2. Rosivatz, E., Matthews, J.G., McDonald, N.Q., et al. A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem. Biol. 1(12), 780-790 (2006).

3. Li, Y., Prasad, A., Jia, Y., et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117(24), 6702-6713 (2011).

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