PAF C-16 Carboxylic Acid (CAS 129879-41-0) | Cayman Chemical
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PAF C-16 Carboxylic Acid

Item № 15392
CAS № 129879-41-0
Purity ≥95%
product image
                (CAS 129879-41-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $99.00 0.00
     1 mg $188.00 0.00
     5 mg $792.00 0.00
     10 mg Contact us

Pricing updated 2018-08-16. Prices are subject to change without notice.

Description
Synonyms
  • CPAGP
  • Platelet-activating Factor C-16 Carboxylic Acid

PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.1 It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6.2,3,4 Pathological processes involving PAF include necrotizing enterocolitis, inflammation, asthma, and allergy.5,6 PAF C-16 Carboxylic acid is modified with a carboxylic acid group terminating the C-16 alkyl chain. This provides a convenient site for chemical crosslinking.

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Technical Information
Formal Name
(R)-7-(acetyloxy)-24-carboxy-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphatetracosan-1-aminium, inner salt, 4-oxide
CAS Number
129879-41-0
Synonyms
  • CPAGP
  • Platelet-activating Factor C-16 Carboxylic Acid
Molecular Formula
C26H52NO9P
Formula Weight
553.7
Purity
≥95%
Formulation
A solution in ethanol
SMILES
C[N+](C)(C)CCOP([O-])(OC[C@H](OC(C)=O)COCCCCCCCCCCCCCCCC(O)=O)=O
InChI Code
InChI=1S/C26H52NO9P/c1-24(28)36-25(23-35-37(31,32)34-21-19-27(2,3)4)22-33-20-17-15-13-11-9-7-5-6-8-10-12-14-16-18-26(29)30/h25H,5-23H2,1-4H3,(H-,29,30,31,32)/t25-/m1/s1
InChI Key
PKDXOBRCEXMRQQ-RUZDIDTESA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 1 year
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Additional Information

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References & Product Citations
Product Description References

1. Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. The Journal of Biological Chemisty 265, 17381-17384 (1990).

2. Carolan, E.J., and Casale, T.B. Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species. Journal of Immunology 145, 2561-2565 (1990).

3. Rouis, M., Nigon, F., and Chapman, M.J. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochemical and Biophysical Research Communications 156, 1293-1301 (1988).

4. Thivierge, M., and Rola-Pleszczynski, M. Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. Journal of Allergy and Clinical Immunology 90, 796-802 (1992).

5. Wang, H., Tan, X.D., Qu, X.W., et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatric Research 42, 597-603 (1997).

6. Sturk, A., Wouter Ten Cate, J., Hosford, D., et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Advances in Lipid Research 23, 219-276 (1989).

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