PAF Receptor (human) Monoclonal Antibody (11A4, Clone 21) | Cayman Chemical
We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

PAF Receptor (human) Monoclonal Antibody (11A4, Clone 21)

Item № 160600
product image
     1 ea $259.00 0.00

Pricing updated 2018-11-19. Prices are subject to change without notice.

  • Platelet-activating Factor Receptor

PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling.1,2,3,4,5 Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain.3,4 In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor.6 Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells.7

Recommended Products

Related Products
View Related Product Categories
Technical Information
  • Platelet-activating Factor Receptor
Synthetic peptide from the internal region of human PAF receptor
Clone Designation
11A4, Clone 21
100 µg of Protein A-purified monoclonal antibody
Storage Buffer
TBS, pH 7.4, when reconstituted in 500 µl of deionized water
(+) ELISA, FC, and ICC; (−) WB
Species Reactivity
  • (+) Human PAF receptor
  • (+) Bovine PAF receptor
  • (+) Porcine PAF receptor
UniProt Accession №

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Nakamura, M., Honda, Z.i., Izumi, T., et al. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes The Journal of Biological Chemisty 266(30), 20400-20405 (1991).

2. Kunz, D., Gerard, N.P., and Gerard, C. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog The Journal of Biological Chemisty 267, 9101-9106 (1992).

3. Ye, R.D., Prossnitz, E.R., Zou, A., et al. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor Biochemical and Biophysical Research Communications 180, 105-111 (1991).

4. Bito, H., Honda, Z.i., Nakamura, M., et al. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA European Journal of Biochemistry 227, 211-218 (1994).

5. Honda, Z.i., Nakamura, M., Miki, I., et al. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung Nature 349, 342-346 (1991).

6. Müller, E., Dagenais, P., Alami, N., et al. Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody Proceedings of the National Academy of Sciences of the United States of America 90, 5818-5822 (1993).

7. Quellet, S., Müller, E., and Rola-Pleszczynski, M. IFN-γ up-regulates platelet-activating factor receptor gene expression in human monocytes Journal of Immunology 152, 5092-5099 (1994).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640