A dopamine receptor agonist
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Analytical Standard(s)
34222(−)-Apomorphine (hydrochloride)
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(−)-Apomorphine (hydrochloride hydrate)

Item No. 16094

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,6aR,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, monohydrochloride, hydrate
CAS Number
58117-94-5
Molecular Formula
C17H17NO2 • HCl [XH2O]
Formula Weight
303.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 15 mg/mlEthanol: 1 mg/ml
λmax
274 nm
SMILES
CN(CC1)[C@]2([H])CC3=CC=C(O)C(O)=C3C4=C2C1=CC=C4.Cl.O
InChi Code
InChI=1S/C17H17NO2.ClH.H2O/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;/h2-6,13,19-20H,7-9H2,1H3;1H;1H2/t13-;;/m1../s1
InChi Key
DQQCJDBYNZMPOA-FFXKMJQXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    (−)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively.1,2 It produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions.1,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Millan, M.J., Maiofiss, L., Cussac, D., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J. Pharmacol. Exp. Ther. 303(2), 791-804 (2002).

    2. Seeman, P., Grigoriadis, D.E., and Niznik, H.B. Selectivity of agonists and antagonists at D2 dopamine receptors compared to D1 and S2 receptors. Drug Dev. Res. 9, 63-69 (1986).

    3. Newman-Tancredi, A., Cussac, D., Audinot, V., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptor. J. Pharmacol. Exp. Ther. 303(2), 805-814 (2002).

    4. Schechter, M.D., Rosecrans, J.A., and Glennon, R.A. Comparison of behavioral effects of cathinone, amphetamine and apomorphine. Pharmacol. Biochem. Behav. 20(2), 181-184 (1984).