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(−)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively.1,2 It produces biphasic effects on locomotor activity and displays anti-
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1. Millan, M.J., Maiofiss, L., Cussac, D., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes J. Pharmacol. Exp. Ther. 303(2), 791-804 (2002).
2. Seeman, P., Grigoriadis, D.E., and Niznik, H.B. Selectivity of agonists and antagonists at D2 dopamine receptos compared to D1 and S2 receptors Drug Development Research 9, 63-69 (1986).
4. Schechter, M.D., Rosecrans, J.A., and Glennon, R.A. Comparison of behavioral effects of cathinone, amphetamine and apomorphine Pharmacology, Biochemistry, and Behavior 20(2), 181-184 (1984).