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(−)-Apomorphine (hydrochloride)

Item № 16094
CAS № 314-19-2
Purity ≥95%
product image
                (CAS 314-19-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     10 mg $35.00 0.00
     50 mg $77.00 0.00
     100 mg $140.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • NSC 11442
  • Uprima

(−)-Apomorphine is a non-selective dopamine receptor agonist that exhibits pKi values of 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively.1,2 It produces biphasic effects on locomotor activity and displays anti-parkinsonian and neuroprotective actions.1,3,4

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Technical Information
Formal Name
5,6,6aR,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, monohydrochloride
CAS Number
314-19-2
Synonyms
  • NSC 11442
  • Uprima
Molecular Formula
C17H17NO2 • HCl
Formula Weight
303.8
Purity
≥95%
Formulation
A crystalline solid
λmax
274 nm
SMILES
CN(CC1)[C@]2([H])CC3=CC=C(O)C(O)=C3C4=C2C1=CC=C4.Cl
InChI Code
InChI=1S/C17H17NO2.ClH/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;/h2-6,13,19-20H,7-9H2,1H3;1H/t13-;/m1./s1
InChI Key
SKYZYDSNJIOXRL-BTQNPOSSSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Millan, M.J., Maiofiss, L., Cussac, D., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes J. Pharmacol. Exp. Ther. 303(2), 791-804 (2002).

2. Seeman, P., Grigoriadis, D.E., and Niznik, H.B. Selectivity of agonists and antagonists at D2 dopamine receptos compared to D1 and S2 receptors Drug Development Research 9, 63-69 (1986).

3. Newman-Tancredi, A., Cussac, D., Audinot, V., et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptor Journal of Pharmacology and Experimental Therapeutics 303(2), 805-814 (2002).

4. Schechter, M.D., Rosecrans, J.A., and Glennon, R.A. Comparison of behavioral effects of cathinone, amphetamine and apomorphine Pharmacology, Biochemistry, and Behavior 20(2), 181-184 (1984).

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