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PluriSln 1

Item № 16161
CAS № 91396-88-2
Purity ≥95%
product image
                (CAS 91396-88-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $49.00 0.00
     10 mg $88.00 0.00
     25 mg $172.00 0.00
     50 mg $245.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • NSC 14613
  • N’-phenyl-hydrazine-Isonicotinic acid

PluriSln 1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (hPSCs).1 PluriSln 1 can selectively induce ER stress, attenuate protein synthesis, and induce apoptosis in hPSCs (EC50 = 2 µM) while sparing progenitor and differentiated cells.1 Because PluriSln 1 can selectively eliminate undifferentiated hPSCs, it was developed as a strategy to prevent tumorigenic risk from residual undifferentiated cells used during stem cell therapy. In immunocompromised mice, PluriSln 1 has been shown to effectively prevent teratoma formation from undifferentiated hPSCs.1

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Technical Information
Formal Name
2-phenylhydrazide-4-pyridinecarboxylic acid
CAS Number
91396-88-2
Synonyms
  • NSC 14613
  • N’-phenyl-hydrazine-Isonicotinic acid
Molecular Formula
C12H11N3O
Formula Weight
213.2
Purity
≥95%
Formulation
A crystalline solid
λmax
271, 235 nm
SMILES
O=C(NNC1=CC=CC=C1)C2=CC=NC=C2
InChI Code
InChI=1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)
InChI Key
HUDWXDLBWRHCKO-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Ben-David, U., Gan, Q.F., Golan-Lev, T., et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen Cell Stem Cell 12(2), 167-179 (2013).

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