Pricing updated 2019-04-24. Prices are subject to change without notice.
Pimozide is an antipsychotic compound that displays high affinity for dopamine receptors (Kis = 2.4, 0.2, and 1.8 nM for D2, D3, and D4, respectively).1,2 It also has actions as an antagonist, inverse agonist, or channel blocker, with lower affinities, at serotonin, α-
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Burstein, E.S., Ma, J., Wong, S., et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-
2. Seeman, P. Atypical antipsychotics: Mechanism of action Can. J. Psychiatry 47(1), 27-38 (2002).
Lau, J.F., Jeppesen, C.B., Rimvall, K., et al. Ureas with histamine H3-
Roufos, I., Hay, S., and Schwarz, R.D. A structure-
5. Cusack, B., Nelson, A., and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds Psychopharmacology (Berl) 114(4), 559-565 (1994).
6. Richelson, E., and Souder, T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds Life Sciences 68(1), 29-39 (2000).
7. Rogers, H.L., Bhattaram, A., Zineh, I., et al. CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: Basis for the US Food and Drug Administration’s new dosing recommendations J.Clin.Psychiatry 73(9), 1187-1190 (2012).