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Item № 16222
CAS № 2062-78-4
Purity ≥98%
product image
                (CAS 2062-78-4)
     50 mg $25.00 0.00
     100 mg $45.00 0.00
     250 mg $99.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

  • NSC 170984
  • Orap
  • R 6238

Pimozide is an antipsychotic compound that displays high affinity for dopamine receptors (Kis = 2.4, 0.2, and 1.8 nM for D2, D3, and D4, respectively).1,2 It also has actions as an antagonist, inverse agonist, or channel blocker, with lower affinities, at serotonin, α-adrenergic, muscarinic cholinergic, and histamine receptors and calcium and sodium channels.2,3,4,5,6 Pimozide is metabolized in the liver primarily by cytochrome P450 (CYP) 3A4, but CYP2D6, an isoform known to be genetically variable, can also affect metabolism.7 Pimozide has diverse neuropathological applications, including in Tourette syndrome.7

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Technical Information
Formal Name
CAS Number
  • NSC 170984
  • Orap
  • R 6238
Molecular Formula
Formula Weight
A crystalline solid
283 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Burstein, E.S., Ma, J., Wong, S., et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist J. Pharmacol. Exp. Ther. 315(3), 1278-1287 (2005).

2. Seeman, P. Atypical antipsychotics: Mechanism of action Can. J. Psychiatry 47(1), 27-38 (2002).

3. Lau, J.F., Jeppesen, C.B., Rimvall, K., et al. Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides Bioorganic & Medicinal Chemistry Letters 16(20), 5303-5308 (2006).

4. Roufos, I., Hay, S., and Schwarz, R.D. A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers Journal of Medicinal Chemistry 39(7), 1514-1520 (1996).

5. Cusack, B., Nelson, A., and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds Psychopharmacology (Berl) 114(4), 559-565 (1994).

6. Richelson, E., and Souder, T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds Life Sciences 68(1), 29-39 (2000).

7. Rogers, H.L., Bhattaram, A., Zineh, I., et al. CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: Basis for the US Food and Drug Administration’s new dosing recommendations J.Clin.Psychiatry 73(9), 1187-1190 (2012).

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