We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Pimozide

Item № 16222
CAS № 2062-78-4
Purity ≥98%
product image
                (CAS 2062-78-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     50 mg $25.00 0.00
     100 mg $45.00 0.00
     250 mg $99.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description
Synonyms
  • NSC 170984
  • Orap
  • R 6238

Pimozide is an antipsychotic compound that displays high affinity for dopamine receptors (Kis = 2.4, 0.2, and 1.8 nM for D2, D3, and D4, respectively).1,2 It also has actions as an antagonist, inverse agonist, or channel blocker, with lower affinities, at serotonin, α-adrenergic, muscarinic cholinergic, and histamine receptors and calcium and sodium channels.2,3,4,5,6 Pimozide is metabolized in the liver primarily by cytochrome P450 (CYP) 3A4, but CYP2D6, an isoform known to be genetically variable, can also affect metabolism.7 Pimozide has diverse neuropathological applications, including in Tourette syndrome.7

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
CAS Number
2062-78-4
Synonyms
  • NSC 170984
  • Orap
  • R 6238
Molecular Formula
C28H29F2N3O
Formula Weight
461.6
Purity
≥98%
Formulation
A crystalline solid
λmax
283 nm
SMILES
FC1=CC=C(C(CCCN2CCC(N3C(NC4=C3C=CC=C4)=O)CC2)C5=CC=C(F)C=C5)C=C1
InChI Code
InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI Key
YVUQSNJEYSNKRX-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Burstein, E.S., Ma, J., Wong, S., et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist J. Pharmacol. Exp. Ther. 315(3), 1278-1287 (2005).

2. Seeman, P. Atypical antipsychotics: Mechanism of action Can. J. Psychiatry 47(1), 27-38 (2002).

3. Lau, J.F., Jeppesen, C.B., Rimvall, K., et al. Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides Bioorganic & Medicinal Chemistry Letters 16(20), 5303-5308 (2006).

4. Roufos, I., Hay, S., and Schwarz, R.D. A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers Journal of Medicinal Chemistry 39(7), 1514-1520 (1996).

5. Cusack, B., Nelson, A., and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds Psychopharmacology (Berl) 114(4), 559-565 (1994).

6. Richelson, E., and Souder, T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds Life Sciences 68(1), 29-39 (2000).

7. Rogers, H.L., Bhattaram, A., Zineh, I., et al. CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: Basis for the US Food and Drug Administration’s new dosing recommendations J.Clin.Psychiatry 73(9), 1187-1190 (2012).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640