Pricing updated 2019-02-20. Prices are subject to change without notice.
1-Azakenpaullone is an analog of kenpaullone (Item No. 10010239) that inhibits glycogen synthase kinase 3β (GSK3β) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively).1 Through its effects on GSK3β, 1-azakenpaullone stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells and Nematostella larvae.2,3,4
Warning - this product is not for human or veterinary use.
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Kunick, C., Lauenroth, K., Leost, M., et al. 1-
Liu, H., Remedi, M.S., Pappan, K.L., et al. Glycogen synthase kinase-
3. Mfopou, J.K., Geeraerts, M., Dejene, R., et al. Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies Stem Cell Res. 12(1), 166-177 (2014).
4. Marlow, H., Matus, D.Q., and Martindale, M.Q. Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis Dev.Biol. 380(2), 324-334 (2013).