1-Azakenpaullone (CAS 676596-65-9) | Cayman Chemical
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Item № 16733
CAS № 676596-65-9
Purity ≥98%
product image
                (CAS 676596-65-9)
     1 mg $74.00 0.00
     5 mg $241.00 0.00
     10 mg $407.00 0.00

Pricing updated 2019-02-20. Prices are subject to change without notice.


1-Azakenpaullone is an analog of kenpaullone (Item No. 10010239) that inhibits glycogen synthase kinase 3β (GSK3β) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively).1 Through its effects on GSK3β, 1-azakenpaullone stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells and Nematostella larvae.2,3,4

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Technical Information
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CAS Number
Molecular Formula
Formula Weight
A crystalline solid
221, 334 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

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Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Kunick, C., Lauenroth, K., Leost, M., et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase- Bioorganic & Medicinal Chemistry Letters 14(2), 413-416 (2004).

2. Liu, H., Remedi, M.S., Pappan, K.L., et al. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets Diabetes 58(3), 663-672 (2009).

3. Mfopou, J.K., Geeraerts, M., Dejene, R., et al. Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies Stem Cell Res. 12(1), 166-177 (2014).

4. Marlow, H., Matus, D.Q., and Martindale, M.Q. Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis Dev.Biol. 380(2), 324-334 (2013).

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