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1-Azakenpaullone

Item № 16733
CAS № 676596-65-9
Purity ≥98%
product image
                (CAS 676596-65-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $74.00 0.00
     5 mg $241.00 0.00
     10 mg $407.00 0.00

Pricing updated 2019-04-23. Prices are subject to change without notice.

Description

1-Azakenpaullone is an analog of kenpaullone (Item No. 10010239) that inhibits glycogen synthase kinase 3β (GSK3β) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively).1 Through its effects on GSK3β, 1-azakenpaullone stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells and Nematostella larvae.2,3,4

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Technical Information
Formal Name
9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one
CAS Number
676596-65-9
Molecular Formula
C15H10BrN3O
Formula Weight
328.2
Purity
≥98%
Formulation
A crystalline solid
λmax
221, 334 nm
SMILES
O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1
InChI Code
InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
InChI Key
NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Kunick, C., Lauenroth, K., Leost, M., et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase- Bioorganic & Medicinal Chemistry Letters 14(2), 413-416 (2004).

2. Liu, H., Remedi, M.S., Pappan, K.L., et al. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets Diabetes 58(3), 663-672 (2009).

3. Mfopou, J.K., Geeraerts, M., Dejene, R., et al. Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies Stem Cell Res. 12(1), 166-177 (2014).

4. Marlow, H., Matus, D.Q., and Martindale, M.Q. Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis Dev.Biol. 380(2), 324-334 (2013).

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