Selective agonist of the EP4 receptor
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CAY10580

Item No. 16835

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid
CAS Number
64054-40-6
Molecular Formula
C19H35NO4
Formula Weight
341.5
Purity
≥96%
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 2.5 mg/ml
SMILES
CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O
InChi Code
InChI=1S/C19H35NO4/c1-2-3-6-9-17(21)13-11-16-12-14-18(22)20(16)15-8-5-4-7-10-19(23)24/h16-17,21H,2-15H2,1H3,(H,23,24)
InChi Key
CBWGHEDGUILASE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $79

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    1 mg

    $147

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    5 mg

    $610

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    10 mg

    $1,065

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    Product Description

    Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.1,2,3 CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively).4 CAY10580 stimulates cAMP formation in excised mouse ovaries.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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