Pricing updated 2019-07-17. Prices are subject to change without notice.
UK 5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC) that inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM).1 It decreases glucose flux to the TCA cycle and increases production of M6 citrate via glutaminolytic flux through malic enzymes without affecting ATP-linked or uncoupled oxygen consumption in C2C12 myotubes when used at a concentration of 10 mM.2 UK 5099 decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES (Item No. 19284) and/or etomoxir (Item No. 11969).
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1. Halestrap, A.P. The mitochondrial pyruvate carrier: Kinetics and specificity for substrates and inhibitors Biochem. J. 148(1), 85-96 (1975).
2. Vacanti, N.M., Divakaruni, A.S., Green, C.R., et al. Regulation of substrate utilization by the mitochondrial pyruvate carrier Mol. Cell 56(3), 425-435 (2014).