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UK 5099

Item № 16980
CAS № 56396-35-1
Purity ≥95%
product image
                (CAS 56396-35-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $29.00 0.00
     5 mg $80.00 0.00
     10 mg $139.00 0.00
     25 mg $254.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

UK 5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC) that inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM).1 It decreases glucose flux to the TCA cycle and increases production of M6 citrate via glutaminolytic flux through malic enzymes without affecting ATP-linked or uncoupled oxygen consumption in C2C12 myotubes when used at a concentration of 10 mM.2 UK 5099 decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES (Item No. 19284) and/or etomoxir (Item No. 11969).

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Technical Information
Formal Name
2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
CAS Number
56396-35-1
Molecular Formula
C18H12N2O2
Formula Weight
288.3
Purity
≥95%
Formulation
A crystalline solid
λmax
210, 250, 383 nm
SMILES
O=C(/C(C#N)=C/C(C1=C2C=CC=C1)=CN2C3=CC=CC=C3)O
InChI Code
InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI Key
BIZNHCWFGNKBBZ-JLHYYAGUSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Halestrap, A.P. The mitochondrial pyruvate carrier: Kinetics and specificity for substrates and inhibitors Biochem. J. 148(1), 85-96 (1975).

2. Vacanti, N.M., Divakaruni, A.S., Green, C.R., et al. Regulation of substrate utilization by the mitochondrial pyruvate carrier Mol. Cell 56(3), 425-435 (2014).

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