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Niclosamide (ethanolamine salt)

Item № 17118
CAS № 1420-04-8
Purity ≥98%
product image
                (CAS 1420-04-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     50 mg $88.00 0.00
     100 mg $167.00 0.00
     250 mg $396.00 0.00
     500 mg $695.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • BAY-73
  • BAY-6076
  • Bayluscide
  • HL 2448

Niclosamide is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models.1,2,3 It inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling.2,4 It completely inhibits phosphorylation of ribosomal S6 kinases (S6K) when used at a concentration of 3 µM.2 Niclosamide (1 µM) induces mitochondrial uncoupling, decreasing cellular ATP concentrations and increasing the ratio of ADP to ATP in HepG2 cells, and activates AMP-activated protein kinase (AMPK) in NIH3T3 cells.3 It also increases lipid oxidation by 5-fold in HepG2 cells. It prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice when administered at a dose of at 125 mg/kg per day.3 Niclosamide also inhibits proliferation and colony formation of DU145 prostate cancer cells, which have constitutively active STAT3 (IC50s = 0.7 and 0.1 µM, respectively).4

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Technical Information
Formal Name
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide compd. with 2-aminoethanol
CAS Number
1420-04-8
Synonyms
  • BAY-73
  • BAY-6076
  • Bayluscide
  • HL 2448
Molecular Formula
C13H8Cl2N2O4 • C2H7NO
Formula Weight
388.2
Purity
≥98%
Formulation
A crystalline solid
λmax
210, 235, 331 nm
SMILES
OC1=C(C(NC2=CC=C([N+]([O-])=O)C=C2Cl)=O)C=C(Cl)C=C1.NCCO
InChI Code
InChI=1S/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;3-1-2-4/h1-6,18H,(H,16,19);4H,1-3H2
InChI Key
XYCDHXSQODHSLG-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Pampori, N.A., Singh, G., and Srivastava, V.M. Energy metabolism in Cotugnia digonopora and the effect of anthelmintics Mol. Biochem. Parasitol. 11, 205-213 (1984).

2. Balgi, A.D., Fonseca, B.D., Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling PLoS One 4(9), 1-15 (2009).

3. Tao, H., Zhang, Y., Zeng, X., et al. Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice Nat. Med. 20(11), 1263-1269 (2014).

4. Ren, X., Duan, L., He, Q., et al. Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway ACS Med. Chem. Lett. 1(9), 454-459 (2010).

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