Pricing updated 2019-07-23. Prices are subject to change without notice.
Niclosamide is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models.1,2,3 It inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling.2,4 It completely inhibits phosphorylation of ribosomal S6 kinases (S6K) when used at a concentration of 3 µM.2 Niclosamide (1 µM) induces mitochondrial uncoupling, decreasing cellular ATP concentrations and increasing the ratio of ADP to ATP in HepG2 cells, and activates AMP-activated protein kinase (AMPK) in NIH3T3 cells.3 It also increases lipid oxidation by 5-fold in HepG2 cells. It prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice when administered at a dose of at 125 mg/kg per day.3 Niclosamide also inhibits proliferation and colony formation of DU145 prostate cancer cells, which have constitutively active STAT3 (IC50s = 0.7 and 0.1 µM, respectively).4
Warning - this product is not for human or veterinary use.
View the Cayman Structure Database for chemical structure definitions for many Cayman products
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
1. Pampori, N.A., Singh, G., and Srivastava, V.M. Energy metabolism in Cotugnia digonopora and the effect of anthelmintics Mol. Biochem. Parasitol. 11, 205-213 (1984).
2. Balgi, A.D., Fonseca, B.D., Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling PLoS One 4(9), 1-15 (2009).
Tao, H., Zhang, Y., Zeng, X., et al. Niclosamide ethanolamine-
Ren, X., Duan, L., He, Q., et al. Identification of niclosamide as a new small-