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Trimethylamine N-oxide

Item № 17354
CAS № 1184-78-7
Purity ≥95%
product image
                (CAS 1184-78-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 mg $25.00 0.00
     1 g $35.00 0.00
     5 g $125.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • NSC 408426
  • TMAO

Trimethylamine N-oxide (TMAO) is a product of the oxidation of TMA by flavin-containing mono-oxygenase 3 in the liver.1 TMAO levels predict risk for atherosclerosis and are elevated in patients with chronic kidney disease and obesity.1,2 TMAO levels are decreased in ulcerative colitis.1 TMAO increases atherosclerosis in ApoE-/- mice, suggesting that TMAO can directly induce cardiovascular disease.1 The biosynthesis of TMA is dependent on gut bacteria, providing a link between the biome and cardiovascular disease.1,2

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Technical Information
Formal Name
N,N-dimethyl-methanamine, N-oxide
CAS Number
1184-78-7
Synonyms
  • NSC 408426
  • TMAO
Molecular Formula
C3H9NO
Formula Weight
75.1
Purity
≥95%
Formulation
A crystalline solid
SMILES
C[N](C)(C)=O
InChI Code
InChI=1S/C3H9NO/c1-4(2,3)5/h1-3H3
InChI Key
UYPYRKYUKCHHIB-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Zhang, L.S., and Davies, S.S. Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions Genome Med. 8(1), 46 (2016).

2. Velasquez, M.T., Ramezani, A., Manal, A., et al. Trimethylamine N-oxide: The good, the bad and the unknown Toxins (Basel) 8(11), E326 (2016).

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