Pricing updated 2019-04-24. Prices are subject to change without notice.
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling.1 BI-2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM).2,3 It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI-2536 induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice.2 It shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.4 BI-2536 is also an inhibitor of BRD4 (IC50 = 25 nM), suppressing BRD4-dependent c-Myc expression in MM.1S multiple myeloma cells.5
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Schöffski, P. Polo-
Steegmaier, M., Hoffmann, M., Baum, A., et al. BI 2536, a potent and selective inhibitor of polo-
Peifer, C., and Alessi, D.R. Small-
Danovi, D., Folarin, A., Gogolok, S., et al. A high-
Ciceri, P., Müller, S., O'Mahony, A., et al. Dual kinase-