We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.


Item № 17385
CAS № 755038-02-9
Purity ≥95%
product image
                (CAS 755038-02-9)
     1 mg $29.00 0.00
     5 mg $94.00 0.00
     10 mg $145.00 0.00
     50 mg $624.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.


Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling.1 BI-2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM).2,3 It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI-2536 induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice.2 It shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.4 BI-2536 is also an inhibitor of BRD4 (IC50 = 25 nM), suppressing BRD4-dependent c-Myc expression in MM.1S multiple myeloma cells.5

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
210, 249, 345 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Schöffski, P. Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology Oncologist 14(6), 559-570 (2009).

2. Steegmaier, M., Hoffmann, M., Baum, A., et al. BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo Current Biology 17(4), 316-322 (2007).

3. Peifer, C., and Alessi, D.R. Small-molecule inhibitors of PDK1 ChemMedChem 3(12), 1810-1838 (2008).

4. Danovi, D., Folarin, A., Gogolok, S., et al. A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1 PLoS One 8(10), 1-13 (2013).

5. Ciceri, P., Müller, S., O'Mahony, A., et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology Nature Chemical Biology 10(4), 305-312 (2014).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640