Pricing updated 2019-07-17. Prices are subject to change without notice.
Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.1 It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.1 CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).1
Warning - this product is not for human or veterinary use.
View the Cayman Structure Database for chemical structure definitions for many Cayman products
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.
Harwood, H.J., Jr., Petras, S.F., Shelly, L.D., et al. Isozyme-