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CP 640,186

Item № 17691
CAS № 591778-68-6
Purity ≥95%
product image
                (CAS 591778-68-6)
     1 mg $35.00 0.00
     5 mg $123.00 0.00
     10 mg $210.00 0.00
     25 mg $438.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.


Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.1 It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.1 CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).1

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A crystalline solid
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Warning - this product is not for human or veterinary use.

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Room temperature in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Harwood, H.J., Jr., Petras, S.F., Shelly, L.D., et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals The Journal of Biological Chemisty 278(39), 37099-37111 (2016).

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