We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.


Item № 17693
CAS № 1594092-37-1
Purity ≥98%
product image
                (CAS 1594092-37-1)
     1 mg $25.00 0.00
     5 mg $88.00 0.00
     10 mg $163.00 0.00
     25 mg $375.00 0.00

Pricing updated 2019-06-15. Prices are subject to change without notice.


Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation.1 It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.2,3 AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively.4 This compound has been used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression.4

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
219, 264, 303 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Becker, W. Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control Cell Cycle 11(18), 3389-3394 (2012).

2. Gao, J., Zheng, Z., Rawal, B., et al. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells Cancer Biology and Therapy 8(17), 1671-1679 (2009).

3. Keramati, A.R., Fathzadeh, M., Go, G.W., et al. A form of the metabolic syndrome associated with mutations in DYRK1B New England Journal of Medicine 370(20), 1909-1919 (2014).

4. Ashford, A.L., Oxley, D., Kettle, J., et al. A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288) Biochemistry Journal 457(1), 43-56 (2014).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640