We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

WAY-262611

Item № 17704
CAS № 1123231-07-1
Purity ≥98%
product image
                (CAS 1123231-07-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $29.00 0.00
     5 mg $102.00 0.00
     10 mg $145.00 0.00
     25 mg $326.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • BML-WN110
  • Dickkopf-1 Inhibitor
  • Dkk1 Inhibitor

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Dickkopf-1 (Dkk1) antagonizes Wnt signaling and has important roles in bone formation, cancer, and Alzheimer’s disease.4 WAY-262611 is an inhibitor of Dkk1 that activates the Wnt signaling pathway, stimulating β-catenin/TCF-dependent transcription with an EC50 value of 0.63 µM.5 It has good pharmacokinetic properties and increases trabecular bone formation in ovariectomized rats following oral administration.5 WAY-262611 has been used to elucidate the role of Dkk1 in modulating Wnt signaling, particularly in the context of arthritis.6,7

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
CAS Number
1123231-07-1
Synonyms
  • BML-WN110
  • Dickkopf-1 Inhibitor
  • Dkk1 Inhibitor
Molecular Formula
C20H22N4
Formula Weight
318.4
Purity
≥98%
Formulation
A crystalline solid
λmax
226, 256, 338 nm
SMILES
NCC1CCN(C2=NC(C3=CC(C=CC=C4)=C4C=C3)=CC=N2)CC1
InChI Code
InChI=1S/C20H22N4/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18/h1-7,10,13,15H,8-9,11-12,14,21H2
InChI Key
QHLITPHIARVDJI-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Polakis, P. Wnt signaling and cancer Genes & Development 14, 1837-1851 (2000).

2. Reya, T., and Clevers, H. Wnt signalling in stem cells and cancer Nature 434, 834-850 (2005).

3. Clevers, H. Wnt/β-catenin signaling in development and disease Cell 127, 469-480 (2006).

4. Hameed, A., Brady, J.J., Dowling, P., et al. Bone disease in multiple myeloma: pathophysiology and management Cancer Growth Metastasis 7, 33-42 (2014).

5. Pelletier, J.C., Lundquist, J.T.t., Gilbert, A.M., et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a winglessβcatenin agonist that increases bone formation rate Journal of Medicinal Chemistry 52(22), 6962-6965 (2009).

6. Enochson, L., Stenberg, J., Brittberg, M., et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition Osteoarthritis Cartilage 22(4), 566-577 (2014).

7. Choe, Y., Hun Kim, J., Park, K.Y., et al. Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid arthritis Rheumatology (Oxford) 29, (2015).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640