Pricing updated 2019-07-17. Prices are subject to change without notice.
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Dickkopf-1 (Dkk1) antagonizes Wnt signaling and has important roles in bone formation, cancer, and Alzheimer’s disease.4 WAY-262611 is an inhibitor of Dkk1 that activates the Wnt signaling pathway, stimulating β-catenin/TCF-dependent transcription with an EC50 value of 0.63 µM.5 It has good pharmacokinetic properties and increases trabecular bone formation in ovariectomized rats following oral administration.5 WAY-262611 has been used to elucidate the role of Dkk1 in modulating Wnt signaling, particularly in the context of arthritis.6,7
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1. Polakis, P. Wnt signaling and cancer Genes & Development 14, 1837-1851 (2000).
2. Reya, T., and Clevers, H. Wnt signalling in stem cells and cancer Nature 434, 834-850 (2005).
Clevers, H. Wnt/β-
4. Hameed, A., Brady, J.J., Dowling, P., et al. Bone disease in multiple myeloma: pathophysiology and management Cancer Growth Metastasis 7, 33-42 (2014).
Pelletier, J.C., Lundquist, J.T.t., Gilbert, A.M., et al. (1-
6. Enochson, L., Stenberg, J., Brittberg, M., et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition Osteoarthritis Cartilage 22(4), 566-577 (2014).
Choe, Y., Hun Kim, J., Park, K.Y., et al. Activation of dickkopf-