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Amidepsine A

Item № 17774
CAS № 169181-28-6
Purity ≥95%
product image
                (CAS 169181-28-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $219.00 0.00
     2.5 mg $438.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • FO-2942A

Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity (IC50 = 10.2 µM in rat liver microsomes).1 It inhibits triacylglycerol formation in Raji cells with an IC50 value of 15.5 µM.1

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Technical Information
Formal Name
2,4-dimethoxy-6-methyl-benzoic acid, 4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenyl ester
CAS Number
169181-28-6
Synonyms
  • FO-2942A
Molecular Formula
C29H29NO11
Formula Weight
567.5
Purity
≥95%
Formulation
A powder
SMILES
OC1=C(C(NC(C)C(O)=O)=O)C(C)=CC(OC(C2=C(O)C=C(OC(C3=C(C)C=C(OC)C=C3OC)=O)C=C2C)=O)=C1
InChI Code
InChI=1S/C29H29NO11/c1-13-8-18(10-20(31)23(13)26(33)30-16(4)27(34)35)40-28(36)24-14(2)9-19(11-21(24)32)41-29(37)25-15(3)7-17(38-5)12-22(25)39-6/h7-12,16,31-32H,1-6H3,(H,30,33)(H,34,35)
InChI Key
XQGKRCPZJSNFEL-UHFFFAOYSA-N
Origin
  • Fungi/Humicola sp. FO-2942

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Tomoda, H., Ito, M., Tabata, N., et al. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties J. Antibiot. (Tokyo) 48(9), 937-941 (1995).

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