We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Voriconazole-d3

Item № 17803
Purity ≥99% deuterated forms (d1-d3)
product image
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 µg $139.00 0.00
     1 mg $250.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description
Synonyms
  • VRC-d3

Voriconazole-d3 contains three deuterium atoms located on the β methyl group. It is intended for use as an internal standard for the quantification of voriconazole (Item No. 15633) by GC- or LC-mass spectrometry. Voriconazole is a triazole, antifungal agent that inhibits a broad range of pathogenic yeasts, including Candida (MIC = 0.03-8 µg/ml), and filamentous fungi such as Aspergillus, Scedosporium, and Fusarium.1,2 Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.2,3,4

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
(αR)-α-(2,4-difluorophenyl)-5-fluoro-βS-methyl-d3-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
Synonyms
  • VRC-d3
Molecular Formula
C16H11D3F3N5O
Formula Weight
352.3
Purity
≥99% deuterated forms (d1-d3)
Formulation
A crystalline solid
λmax
205, 255 nm
SMILES
FC1=CN=CN=C1[C@@H]([C@](O)(CN2N=CN=C2)C3=C(C=C(C=C3)F)F)C([2H])([2H])[2H]
InChI Code
InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1/i1D3
InChI Key
BCEHBSKCWLPMDN-QLWAGJNOSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005).

2. Delattin, N., Cammue, B.P.A., and Thevissen, K. Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms Future Med.Chem. 6(1), 77-90 (2014).

3. Munayyer, H.K., Mann, P.A., Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds Antimicrobial Agents and Chemotherapy 48(10), 3690-3696 (2004).

4. Warrilow, A.G., Melo, N., Martel, C.M., et al. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-a demethylase (CYP51) isoenzymes A and B Antimicrob. Agents Chemother. 54(10), 4225-4234 (2010).

Technical Support
FAQ

It appears that there is a heterogenous mixture of deuterated species in your deuterated standards; is this normal?

Yes, this is typical of our deuterated products. Our deuterated products contain less than 1 % d0. However, the labeled compounds are not 100% of the deuterated form listed on our product insert. For example, upon analysis of 2-arachidonoyl glycerol-d8 it is expected to see masses associated with the d7, d6, d5 etc.

Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640