Prostaglandin I2 (sodium salt) (CAS 61849-14-7) | Cayman Chemical
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Prostaglandin I2 (sodium salt)

Item № 18220
CAS № 61849-14-7
Purity ≥98%
product image
                (CAS 61849-14-7)
     1 mg $56.00 0.00
     5 mg $252.00 0.00
     10 mg $420.00 0.00
     25 mg $980.00 0.00

Pricing updated 2018-11-16. Prices are subject to change without notice.

  • Epoprostenol
  • PGI2
  • Prostacyclin

Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells.1,2,3 It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM.4 PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.5

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Technical Information
Formal Name
6,9α-epoxy-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt
CAS Number
  • Epoprostenol
  • PGI2
  • Prostacyclin
Molecular Formula
C20H31O5 • Na
Formula Weight
A crystalline solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Moncada, S., Gryglewski, R., Bunting, S., et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Nature 263, 663-665 (1976).

2. Johnson, R.A., Morton, D.R., Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin) Prostaglandins 12(6), 915-928 (1976).

3. Stehle, R.G. Physical chemistry, stability, and handling of prostaglandins E2, F, D2 and I2: A critical summary Methods Enzymol. 86, 436-459 (1982).

4. Aristoff, P.A., Johnson, P.D., and Harrison, A.W. Synthesis of 9-substituted carbacyclin analogues J. Org. Chem. 48, 5341-5348 (1983).

5. McLaughlin, V.V., Genthner, D.E., Panella, M.M., et al. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension New England Journal of Medicine 338, 273-277 (1998).

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