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Item № 18293
CAS № 1393371-39-5
Purity ≥98%
product image
                (CAS 1393371-39-5)
     500 µg $38.00 0.00
     1 mg $65.00 0.00
     5 mg $247.00 0.00
     10 mg $418.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.


MHY908 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ that increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells when used at a concentration of 5 µM.1 In vivo, MHY908 (3 mg/kg per day) reduces serum glucose, triglyceride, and insulin levels and improves hepatic steatosis by reducing hepatic triglyceride levels and lipid droplet accumulation in db/db mice and 20-month-old rats.1,2 It reduces peroxynitrite and COX-2 levels, reactive oxygen species (ROS) production, and Akt phosphorylation in isolated kidney from 20-month-old rats when administered at a dose of 3 mg/kg.2 MHY908 inhibits mushroom tyrosinase (IC50 = 8.19 µM).3 It also inhibits increases in melanin content in α-melanocyte stimulating hormone-induced B16/F10 murine melanoma cells when used at a concentration of 10 µM.

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Technical Information
Formal Name
2-[4-(5-chloro-2-benzothiazolyl)phenoxy]-2-methyl-propanoic acid
CAS Number
Molecular Formula
Formula Weight
A crystalline solid
217, 310, 324 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Park, M.H., Park, J.Y., Lee, H.J., et al. Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice PLoS One 8(11), e78815 (2013).

2. Park, M.H., Kim, D.H., Kim, M.J., et al. Effects of MHY908, a new synthetic PPARα/γ dual agonist, on inflammatory responses and insulin resistance in aged rats J. Gerontol. A Biol. Sci. Med. Sci. 71(3), 300-309 (2016).

3. Park, M.H., Kim, S.J., Jeong, H.O., et al. Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908) Arch. Pharm. Res. 38(4), 505-511 (2015).

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