Pricing updated 2019-06-15. Prices are subject to change without notice.
Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.1 MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).2 It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.2 See the Structural Genomics Consortium (SGC) website for more information.
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1. Yang, Y., and Bedford, M.T. Protein arginine methyltransferases and cancer Nature Reviews.Cancer 13(1), 37-50 (2013).
Eram, M.S., Shen, Y., Szewczyk, M.M., et al. A potent, selective, and cell-