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MS023 (hydrochloride)

Item № 18361
CAS № 2108631-19-0
Purity ≥95%
product image
                (CAS 2108631-19-0)
     1 mg $45.00 0.00
     5 mg $203.00 0.00
     10 mg $360.00 0.00
     25 mg $788.00 0.00

Pricing updated 2019-06-15. Prices are subject to change without notice.


Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.1 MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).2 It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.2 See the Structural Genomics Consortium (SGC) website for more information.

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Technical Information
Formal Name
N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine, trihydrochloride
CAS Number
Molecular Formula
C17H25N3O • 3HCl
Formula Weight
A crystalline solid
250 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Yang, Y., and Bedford, M.T. Protein arginine methyltransferases and cancer Nature Reviews.Cancer 13(1), 37-50 (2013).

2. Eram, M.S., Shen, Y., Szewczyk, M.M., et al. A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases ACS Chemical Biology 11.8.15, (2015).

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