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15-deoxy-Δ12,14-Prostaglandin J2

Item № 18570
CAS № 87893-55-8
Purity ≥95%
product image
                (CAS 87893-55-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     100 µg $25.00 0.00
     500 µg $68.00 0.00
     1 mg $98.00 0.00
     5 mg $375.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • 15-deoxy-Δ12,14-PGJ2

15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1

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Technical Information
Formal Name
11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid
CAS Number
87893-55-8
Synonyms
  • 15-deoxy-Δ12,14-PGJ2
Molecular Formula
C20H28O3
Formula Weight
316.4
Purity
≥95%
Formulation
A solution in methyl acetate
λmax
229, 306 nm
SMILES
O=C1/C([C@@H](C/C=C\CCCC(O)=O)C=C1)=C/C=C/CCCCC
InChI Code
InChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
InChI Key
VHRUMKCAEVRUBK-GODQJPCRSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation Cell 83(5), 813-819 (1995).

2. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 83(5), 803-812 (1995).

Product Citations

Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays Sci. Data 5:180167, (2018).

Reddy, A.T., Lakshmi, S.P., Banno, A., et al. Identification and Molecular Characterization of PPARδ as a Novel Target for Covalent Modification by 15-deoxy-Δ12, 14-prostaglandin J2 ACS Chem. Biol. (2018).

Grabocka, E., and Bar-Sagi, D. Mutant KRAS enhances tumor cell fitness by upregulating stress granules Cell 167(7), 1803-1813 (2016).

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